Fillagrin. Skin barrier.

 

Melanin pun natural sunscreen.

Leptin sensitive = better thermoregulation via autonomic nervous system.

Fillagrin which is built by UV conferred barrier function.

Fillagrin adalah barrier atau penghadang untuk menjaga kulit dari senang di serang anasir luar. Fillagrin dibuat oleh cahaya uvb.

Filaggrin kita dekat khatulistiwa lebih developed dari org kulit cerah di latitude tinggi. - M

Eczema fillagrin = tak cukup.

Accordingly, centralized science has identified a higher prevalence of filaggrin mutations in northern European populations when compared to more southern European, Asian, and African populations that correlate significantly with differences in circulating 25-OH-Vitamin D3 levels in these populations. - Dr JK

Bagaimana nak bina natural sunscreen (sun callus).?

 Bagaimana nak bina natural sunscreen (sun callus).?

1) Betolkan Circadian Rhythm (filaggrin) 2) Redlight (filaggrin) 3) UVA (filaggrin-urocanic acid, melanin) 4) UVB (cathelicidin)

-Filaggrin fx utk provide physical barrier ,hydration dan penghasilan urocanic acid -Urocanic acid provid slightly low ph dan kasi photoprotection bila terdedah dgn UV -Melanin prevent DNA damage to keratinocyte -Cathelicidin promote skin regeneration

Selain itu pengambilan DHA dan Astaxanthin juga dpt menolong mengurangkan oxidative damage.

tanpa Bmal1 gene (circadian gene), Filaggrin gene berkurangan.

Infrared radiation induce Filaggrin production

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957604/

Histidine , aromatic amino acid which absorb UV light act as a precursor to formation of urocanic acid (UCA)

DHA act as a photoprotective macronutrient

https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2011.01294.x

Astaxanthin protect us from UV

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073124/

Filaggrin

Sunrise and Am sun buat kerinocytes ( cell kulit ) produce pro filaggrin. Pro filaggrin act as physical barrier and retain moisture 

Bagaimana nak bina natural sunscreen (sun callus).? 1) Betolkan Circadian Rhythm (filaggrin) 2) Redlight (filaggrin) 3) UVA (filaggrin-urocanic acid, melanin) 4) UVB (cathelicidin)

All component (PUFA, Keratin, Collagen, Melanin) yg attribute to sun callus buat keje dgn kasi kulit keupayaan untuk tukarkan high energy UV into DC electric current with minimal oxidative stress.

Melanin menghalang sinaran UV tembus kedalam nucleus sel sel kulit dan juga berupaya sebagai antioksida yang mengurangkan oksidatif stress.