Methtylation

 Since folate destroy by UV during the day, does that means that our homocysteine slightly elevated during the day?

Methtylation and transulfuration activities reduce waktu pagi???

Yg ni ambo xfaham, klau sunlight tolong methylation by TET enzyme utk demethylation , it only cover DNA methylation. Utk detox, neurotransmitter still rely on vit B. B9 n B12 smua essential vit yg kita perlu mkn. Or JK just nk ckp yg redox boleh bntu bdn kita simpan vit ni?

Klau mlm badan kita buat methylfolate and methylfolate utk remethylation of homocysteine kpd SAMe. Yg ni mostly happen dekat mito, so ad kaitan dgn redox. So basically fx form of b9 and 12 yg digunakan utk methylation happen dlm 1 carbon cycle which mainly take place in mito

So sunlight = redox = optimal methylation.

Hypermethylation and hypomethylation boleh contribute to cancer. Hypermethylation of tumour suppressor genes Hypomethylation of oncogenes Ingat methylation = gene silencer